Low StockNAD+
500mg | $129.00pH buffered
NAD+ is the molecule that connects energy production to cellular maintenance. It carries electrons through the respiratory chain for ATP synthesis, and the same supply is consumed by enzymes that adjust gene expression, coordinate circadian timing, and execute DNA repair.
This shared dependence makes NAD+ central to research on aging, metabolic resilience, and how tissues maintain function under sustained demand.
- ATP ProductionCarries electrons from nutrient breakdown to the mitochondrial respiratory chain, where they drive ATP synthesis. This cycling is continuous—NAD+ is recycled, not consumed.
- Metabolic and Circadian AdaptationConsumed by sirtuin enzymes when they adjust gene expression for stress responses, metabolic flexibility, and circadian timing. Unlike electron transport, this is irreversible—the molecule is cleaved.
- DNA Damage ResponseConsumed by PARP enzymes during DNA strand break detection and repair. Sustained damage from oxidative stress or inflammation keeps PARPs active and draws heavily on NAD+ supply.
- Why Availability DeclinesCD38—an enzyme on immune and endothelial cells—degrades NAD+ during inflammatory signaling. Its expression rises with age and inflammation, making it the dominant driver of tissue NAD+ decline.
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For in-vitro laboratory research use only. Not for human consumption.